Transporters are a class of surface proteins that aid molecules in crossing s membranes. These membranes are often impermeable to large or hydrophilic molecules, and thus greatly restrict or completely block molecular movement into or out of the cell or even into or out of the human body. Transporters, consisting of the ABC and SLC superfamilies, are one way the human body overcomes this to allow these molecules, such as nutrients and medications, to cross these barriers and distribute in the body.
Our research falls into two categories, developing therapeutics and developing genetic based diagnostic tests to aid medication selection and dosing.
Targeting Membrane Transporters For Better Therapies
Membrane transporters play a role in variety of diseases, including cancer, diabetes and cardiovascular disease, yet they have largely gone uncharacterized as drug targets. At Apricity, we are using our expertise in transporter biology and pharmacology to develop transporter-targeted therapies. Our first application of this technology is in cancer, where tumor cells support their rapid growth by using transporters to accumulate essential nutrients such as sugars, nucleosides and amino acids. Apricity is working to modify approved anti-cancer drugs to better target cancer cells while leaving healthy cells free from potentially toxic medications, thereby increasing therapeutic effectiveness while reducing harmful side effects.
Apricity has great expertise in studying transporters and offer various services to academia and industry. For more information about these services, including pricing, please contact us.